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Alzheimer's disease is the most common form of dementia, and affects an estimated 5% of individuals over age 70, with 25% of all cases being familial (two or more affected individuals within a family).
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Early-onset AD makes up approximately 1-5% of all cases of Alzheimer's disease, with a prevalence of 41.2 per 100,000 individuals aged 40-59 years.

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Considerations for Testing

A genetic cause for Alzheimer's disease may be suspected in individuals who have:

• A clinical diagnosis of early-onset Alzheimer's disease (onset before 60 years of age), and a family history of dementia or related conditions

• No personal history of AD but who are known to be at risk for a hereditary form of Alzheimer's disease because of family history

In addition to meeting one of the above criteria, individual's considering genetic testing for hereditary forms of Alzheimer's disease should first receive thorough pre-test genetic counseling from a professional qualified to fully understand the implications of testing for neurodegenerative disorders that have no known treatment or cure at this time. 

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